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What is Acral peeling Skin Syndrome?
Acral skin undress syndrome is a rare genetic precondition that conduce to painless peeling of the top layers of the skin on the deal and base . And can also affect the skin of the weapon system and legs . Acral skin discase syndrome was first describe by Dr. Howard Fox in a sheath letter and since then 100 cases have been reported in the aesculapian literature(1,2 ) . The symptoms of Acral skin skin syndrome are mild and do not affect the timber of life .
What Causes Acral Peeling Skin Syndrome?
Acral peeling cutis syndrome is join with mutations in factor transglutaminase 5 ( TGM5 ) and less commonly with mutations in gene cystatin A ( CSTA ) .
TGM5 signalize the torso to create the TGM5 enzyme that is found in the tissues include the epidermis . This enzyme create cornified cells that spiel the role of a protective barrier between the skin and the outside domain . If the TGM5 enzyme is not created the outermost layer of the hide stays unprotected and peels off . It mostly impact the hands and pes as these are the part of the body expose to most rubbing .
CSTA cistron signals the release of CSTA enzyme that plays a role in cell to cell adhesion(3 ) .
The gene mutations linked with acral pare tegument syndrome are inherit in autosomal recessive trait , which means a copy of the mutated gene needs to be received from both parents . If it is received from one parent then the person is a carrier and does not spring up symptom . If both the parents have gene mutations there are 25 percent chances of the kid develop the symptoms , 50 % chances of the child carry the cistron , and 25 % luck of neither developing the gene nor transport the symptoms(4 ) .
Symptoms of Acral Peeling Skin Syndrome
In acral peeling skin syndrome , there is discase of the skin of the top layer called the cuticle . The peeling is seen affecting the hands and feet but can also affect the arms or legs .
Other symptoms of Acral skin peeling syndrome include plucked hair and fragile skin . There is itching and redness of the peel under the peeling tegument .
The peeling is seen pass from birth but can appear later in childhood as well . A case study done in 2016 found a child developing blisters and peel in palms and sole from the age of 6 months(5 ) .
The peeling in Acral skin peeling syndrome is known to worsen from heat , humidness , and wet .
The status does not affect the quality of life and is also not consort with any other health condition .
Diagnosis and Treatment of Acral Peeling skin syndrome
Acral unclothe pelt syndrome is mostly diagnose in other childhood . But , in some cases , it remains undetected until adulthood as regain in a case study in 2014(6 ) .
If the condition is suspected , a kinfolk medical history is have and a physical test is done . To confirm the diagnosis , a sampling of the pelt is taken for testing TGM5 and CSTA gene mutations .
The treatment of acral peeling skin syndrome mostly involves managing the symptom . cure the condition completely is not potential . Medical treatment is not necessary usually . If a bulla is develop , it is lance by the doctor with a sterile needle to drain the fluid and a light medical dressing is use to avoid the infection .
Home Remedies
The symptoms of Acral hide peeling syndrome can be contend at family with the aid of a moisturizer scream cream . These help in comfort the skin and preventing drying and flaking as they enshroud the skin under a thick oily bed that help seal in the wet . These can be used in the physique of creams , lotion , nebulizer , or ointments .
The Acral skin strip down syndrome symptoms can also be managed by avoiding the following :
If you suspect that your tyke has acral peeling skin syndrome , a medico should be consulted . A proper diagnosing can be extremely in managing the symptoms of the condition .
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