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Can A Stem Cell Transplant Cure Multiple Myeloma?

There is no cure for multiple myeloma ( MM ) the cancer can be controlled to some level with handling . A base electric cell transplant , it is one of the treatment method of multiple myeloma and most patients go to a remission stage after stem cadre transplant but Cancer the Crab recurs after some meter . It is not a remedy but most patient remain in remission for years after stem cell transplanting .

Hematopoietic stem cells are produced by thebone vegetable marrow , to recollect cells for transplantation stem cell growth factors are injected to the affected role or the donor , then the bone marrow releases the stalk cell to the bloodstream . These prison cell are harvested from the bloodline and lay in appropriately to use in the future .

There are main 2 case of stem cell transplants

Autologous Transplants

In autologous transplant , patient role ’s own stem turn cubicle either from the bone marrow or peripheral blood ( now mostly harvested from peripheral blood ) is take away or stack away .

Then , the patient undergoes chemotherapy with or without radiation therapy to destroy the myeloma cell ( intelligent bone marrow cells are also destroy in this physical process ) . Then the stem cells are reassign back to the patient ’s pedigree so as to produce new haematopoietic cells . This is a standard treatment for multiple myeloma patient and most of the time the myeloma goes away but it comes back after a few eld .

Tandem Transplant – This is having 2 autologous transplantation in 6 - 12 month aside with medication / chemotherapy in between the transplant . This method may be effective than having just one transplant but the side effects are quite gamy .

Allogenic Transplants

In allogeneic graft , radical cells are taken from a presenter . The success of the transplantation is more if the bestower is a relative such as a crony or a sister of the affected role , then the stalk jail cell have more similarities . These transplanted cells can oppose the remaining myeloma cells and ruin them . However , this transplant is not considered now as many affected role had a hapless short - terminal figure outcome.(1 )

The Success Rate Of Stem Cell Transplant

Studies have prove that chemotherapy with autologous transplant has shown a upright response to treatment and the 5 - year even free menstruation was also increase when compare with conventional therapy .

study done on single autologous transplantation and tandem transplant show that tandem bicycle transplant success pace is superior , these patients have near - complete reception pace , fewer reverting , and increased event - free natural selection . Studies have found out that the long - full term result from tandem transplantation is more compared to the usual autologous transplanting and this outcome is much more if the affected role is pass on a high Cupid’s disease of chemotherapy . However , there is no literal remainder in the natural selection pace in both transplantation methods . The chemotherapy dose and a number of transplants should be adjudicate according to the single patient and this decision will be take by the team require with the patient ’s treatment .

Allogenic transplants are not done much because the transplant - related deathrate is high-pitched and most patient explicate knottiness such as bribery - versus - legion disease ( the donor resistant cells attack the patient role ’s body identifying those as extraneous cells ) . It is record that the death charge per unit after 100 sidereal day of allogeneic transplant range from 10 - 56 % .

Another retrospective case survey show that the average survival rate after autologous transplant is about 34 calendar month whereas after allogeneic transplant it is about 18 months.(2 )

Conclusion

theme cell transplant is not a cure formultiple myeloma ; it is another treatment modality for multiple myeloma patient so that they go into a Cancer the Crab remission stage for a sealed period , butcancerrecurs after some sentence . There are two main types of base cell transplant : autologous and allogeneic transplant . Autologous transplanting is used mostly as the complication are less and the survival rates are in high spirits when equate to allogeneic transplant . Tandem transplantation is a variation of autologous transplant where the patient undergoes two autologous transplants within 6 - 12 months and in between chemotherapy / irradiation is give to ruin the myeloma cells . Studies have shown that the reply charge per unit , relapse - free survival , and outcome - free survival rates are high with bicycle-built-for-two transplantation .

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