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Can HLA B27 Change From Positive To Negative?
Have you or anyone you know experienced this ? After having a prescribed HLA - B27 test , has it tuned to negative or vice versa ?
Technically speaking , a prescribed HLA b27 can never turn minus and vice versa . The reasonableness for this is , HLA - b27 is a genetical marker and this works like a descent radical , which never change . So , what seemingly makes a HLA b27 change from positive to negative ? To understand this you need to understand the method of testing HLA - B27 cistron .
The HLA - B27 test is done using three unlike ways :
The PCR establish method is the most precise of all the tests for HLA B27 testing.(1)Some patient who have tested negative using the flowing cytometry method have a positive result when tested using the PCR method.(1 )
Flow cytometry test can also give inconclusive theme , which involve to be check off again using the PCR based method . So , this is the reason how a positively charged HLA b27 can turn negative and vice versa and the reason of the variance in the tests .
So , it is important to front into the method of the test used when you are getting HLA B27 checked , as the chosen method acting can be creditworthy for the result of delusive electropositive and vice versa .
Are You Born With HLA B27?
Yes , HLA B27 is present from parturition , as it is a genetic variability . make HLA B27 increase the risk for sure diseases.(2)HLAs or human leukocyte antigens are protein that are present on white blood cells and serve the organic structure ’s immune system differentiate between foreign substances and healthy body tissue paper that can cause contagion in the body .
Majority of the HLAs service in protect your body ; however , this particular HLA - B27 is a protein that leads to disfunction in the immune system.(4)The HLA - B27 present on the blanched blood cells can lead in the body ’s immune system attack the levelheaded prison cell result in immune - mediated disease or an autoimmune disease , such asankylosing spondylitisor juvenilerheumatoid arthritis.(2 , 3 )
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