Mixed connective tissue disease is a rare autoimmune upset mainly affecting multiple joints of the body . It has feature film of rheumy diseases such asSLE , scleroderma , polymyositisandRheumatoid arthritis . It is more prevalent in woman in the age group of 20 to 30 eld .
Can Mixed Connective Tissue Disease Be Reversed?
Since motley connective tissue involves polarity and symptom from multiple disorders , it is difficult to carry off . sundry connective tissue disease has no remedy , only the symptoms can be managed with right discourse . Mixed connective tissue disease is a reform-minded disease and mostly can not be invert . It can involve many dissimilar organ at one time making the handling difficult along with further risk of evolve complication . Sometimes lifelong handling might be required in severe cases . Monitoring of the signs and symptom is necessary to prevent adverse effect . The prognosis depends on the severity of the symptom and the extent of involvement of various organs . The patient role is also advise to make modus vivendi modification and take a healthy diet rich invitamin D , and antioxidant andavoid smokingandalcohol abuse . All these measures when necessitate with proper medication can help manage the symptom .
Symptoms Of Mixed Connective Tissue Disease
It is know to have lap symptom of many connective tissue disorders . The earliest symptom to seem is the Raynaud ’s disease where the fingers or toes go asleep and cold in reception to low temperature and stress . The fingers and toes first become snowy followed by purplish blue and then when the stemma returns to the periphery they turn red . It mostly come about as a compensatory mechanism to conserve heating in the eubstance so the blood flow to the peripheral tissues is restricted to forestall exit of heat . later on other organs take up to get affected as well . Other symptom include muscular tissue and joint pain sensation , weakness and tendency to get tired well due to inflammation of the muscle radical acquaint there , low grade fever , nuisance in abdomen , nerve upset and difficulty in hearing . Esophageal dysfunction leads to heartburn and gastric ebb of acid along with trouble in ingesting solid nutrient bolus . Most of the patients with mixed connective tissue disease develop lung disease after a point of time . It can lead to significant difficulties in breathing that can either be due to rubor of the lung tissue paper or scarring of the alveoli ( interstitial lung disease ) or due to increase in pressure in the pulmonary arteries ( pulmonary hypertension ) .
Skin change include inflammation and rashes on the peel along with hair’s-breadth loss over the affected expanse of human face and hand . The marred tissue can mostly be seen in area that are exposed to sun more . There can be swell and numbness over the finger and toes . Cardiac and renal interest might also be present in about 10 % of the cases with motley connective tissue paper disease . Some pillowcase might also deliver with neurological disorder associated with mixed connective tissue disease . In about 30 to 40 percent of the cases , there are also down levels of red blood mobile phone reckoning and hemoglobin along with decreased white blood prison cell count . Enlarged lymph nodes , short temper ( splenomegaly ) and liver ( hepatomegaly ) is also visualize in many cases . There can also be interest of the abdominal and intestinal tissues .
The accurate cause of mixed connective tissue paper disease still stay unknown . It is seen to be genetically predispose where the RNP antibodies are passed on that termination in attacking of its own salubrious cellular phone .
Treatment Of Mixed Connective Tissue Disease
Once assorted connective tissue paper disease has been diagnose the aim of treatment is to unbosom the patient of symptoms since it can not be cured . vasodilative are give to treat Raynaud ’s disease , proton pump inhibitors for gastric reflux disease and DMARDs for symptoms of arthritis . Low sexually transmitted disease corticosteroids are order for check the flare symptoms . They might even be demand to be cave in for a longsighted period of time despite their longsighted - terminal figure side effects and perniciousness . NSAIDs are pass on to curb seditious diseases under the supervision of a doctor as they can lead to gastric problems . Immunosuppressant therapy is also required in some wicked cases .
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