Thalassemia is a genetical disorder get due to the mutation in genes responsible for the formation of hemoglobin . Thus , unnatural hemoglobin lead to downcast level ofred blood cellscausinganemia . Various discussion strategies , depending upon the severity , are adopted by medical professionals .
Can Thalassemia Be Cured?
Blood Transfusion : Thalassemia is the experimental condition characterized by the production of unnatural hemoglobin . As the number of red blood cells lessen , anemia may arise . The development of anemia may cause tiredness and pale skin . Blood transfusion is the backbone for the treatment of thalassemia major . This helps in the replenishment ofhemoglobinand red blood cell chair to improve the symptoms of anemia . Patients with severe thalassemia ask 10 - 12 blood transfusion in a year while with less severe Mediterranean anaemia require 7 - 8 transfusions per year . The blood transfusion is increase in the conditions when more zip and oxygen is postulate such as strain , infection , and unwellness .
Stem Cell Transplant : Thalassemia is the precondition of organization of abnormal haemoglobin and red line of descent cells . Thalassemia also cause a reduction in red blood cells . The main abnormality hap in the erythropoiesis summons in thebone marrow , thus bone bone marrow transplantation is another viable pick for the direction of the disease . The stem prison cell transplantation regard three important processes for transplant new bone marrow :
Gene Therapy : The disease is induce due to the genetical variation which results in the output of abnormal hemoglobin . Thus , gene therapy is an important and workable approach for the discourse of thalassemia . Gene therapy can be done through a variety of process including the transfer of gene through oncoretroviral or lentiviral vector . The other methods which can also be used include stop - codon read through and splicing - switching .
Iron Chelators : The red blood cellular phone are destroy at a higher rate as compared to the normal person lead to accrual of iron in the organic structure . Further , a blood transfusion , which is the primary therapy for Mediterranean anaemia , also increase the concentration of atomic number 26 in the body . This final result in iron overload and iron toxicity . This increases the accumulation of Fe in vital organs such as the liver and heart . Iron chelators are used to chelate the excess iron from the blood . The drugs used are deferoxamine or deferasirox .
Surgery : As the body is deficient of red blood line cellular phone which lead in anemia , the osseous tissue center is under high pressure to produce RBC . This results in the bone deformation . To correct the pearl deformation , surgery is want .
Generating Fetal Hemoglobin : This approach is under clinical trials and is currently not available to patients of thalassemia . The fetal hemoglobin inducers are administered to the affected role and the severity of the disease is keep down . A study reason that almost 50 % of the patient reply to the discourse . Hydroxyurea is generally used as foetal hemoglobin persuader .
The discourse depend upon the case and severity of thalassemia . Various treatments let in origin transfusion , stem cellphone transplant , surgery and use of branding iron chelators . Therapy - related to fetal haemoglobin inducers is currently under clinical trial .
Also scan :
