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Clotting of lineage is a rude response of the trunk to any open wound or combat injury . A Blood Clot develops when the blood modify into a semi - solid state at the site of the injury or wound to prevent any supernumerary blood going . There are various chemical operation that results in curdling of blood . Once the wound heals the clot dissolves on its own .
It is quite common to see descent clot on the skin surface after an accidental injury . However , sometimes , ancestry clot can form in veins which can be very serious and living threaten . These types of descent clots do not break up ad lib and in fact mar adequate rake stream through the vein . This at times can even be fatal for the person.[1 , 2 , 3 ]
Sometimes , a coagulum formed at a particular part of the body can break off and get lodged in some other part . This is medically bonk as intercalation . If this clot reaches the brain , heart , or lung it can cause extremely serious complications like a stroke or a myocardial infarct . Some of the symptoms of intercalation admit persistent cough , hemoptysis , severe pain in the extremities , acute chest pain andshortness of breath.[1 , 2 , 3 ]
With gaze to blood clot and the human relationship that it share with COVID-19 is being much speak about by researchers these days . There is continue evidence emerge that COVID-19 can indeed cause rakehell clots . This has been run across in about 30 % of critically ominous patient who have a known diagnosing of COVID-19.[1 , 2 , 3 ]
Some researchers are of the belief that pedigree curdling is one of the main features of COVID-19 but what has baffled them the most is the intro of the blood coagulum and not the comportment of it.[1 , 2 , 3]This article throws more light into the relationship between COVID-19 contagion and blood clots .
COVID-19 & Blood Clots: Is There A Link?
An clause in Nature mentions that researchers are still not sure as to why COVID-19 causes blood coagulum . However , they have come up with multiple theories . According to one theory , coagulate happens when the virus attacks the endothelial cells lining the blood vessel . During this process the virus bind to the ACE2 sensory receptor that are by nature present in the endothelial cubicle tissue layer . Once the binding outgrowth is over , the blood vessels start unfreeze a protein that push blood clotting.[3 ]
Another theory propose that COVID-19 causes the resistant system to trigger an seditious reply . This inflammatory response in turn spark off clotting . There are other external factors as well that are at play in people with COVID-19 who develop clotting . These let in age above 65 , beingoverweight , chronicle of hypertension anddiabetes , and being on medications that increase likelihood of blood clotting.[3 ]
research worker evoke that the line clotting that is run across in the great unwashed with COVID-19 is quite different from that seen in people without this stipulation who have had history of stroke or pulmonary embolism . It has been observe that the stock coagulum in hoi polloi with COVID-19 pattern in the lung , which is not the face usually . A parentage clot generally mold at other part of the body which then give away off and gets lodged in the lungs . The clots visit in mass with COVID-19 tend to form in small blood vessels of the lung instead of major blood vessels such as that seen in people with stroke.[3 ]
There is also one field which consists of data of 11 citizenry who knuckle under to COVID-19 . The autopsy review of these 11 mass distinctly states that all of them had stock clot but they never receive a diagnosis of it when they were alive . After examine the data , the researchers were of the view that these blood clots were the actual drive of demise in these 11 mass even though 10 of them did receive anticoagulation medications.[3 ]
Researchers are also of the view that excessive blood clotting in COVID-19 patients is one of the main causes of major complications that are hear from this infection . enquiry studies also suggest that hoi polloi with COVID-19 who have line of descent clots are more likely to require intensive fear treatment and have far spoiled medical prognosis than mass who do not have it.[3 ]
What Are The Current And Upcoming Treatments?
Almost all COVID-19 patients are now being give blood thinners and anticoagulation medications . This is done while the patient role is in the infirmary and is recommended to continue for at least two workweek after discharge to minimize the risk of blood clot due to COVID-19 . However being on blood thinners increase the chances of leisurely bleeding and thus these medications are not suited for high risk people.[3 ]
There have been account of some people who were on ventilators due to COVID-19 and were also on line thinners had humble prospect of surviving than people who did not take blood line thinners . New avenues and therapy are now being looked at to assay and prevent and address lineage clot that are caused due to COVID-19 . Researchers are comparing standard doses of blood dilutant with higher doses that are founder to critically sick patients . More potent medications like plasminogen activators are also being tested to care for lineage clots due to COVID-19.[3 ]
In ratiocination , there is no unmortgaged grounds known to researchers as to why COVID-19 causes blood clot in some patient . They have come up with some theory which have been detail above that might be the rationality as to why COVID-19 patients develop lineage clots.[1 , 2 , 3 ]
A unique thing that is have intercourse about the line of descent clots formed due to COVID-19 is that in almost all the lawsuit the clot are form in the lungs and that too in small blood vessel and the major vessels are give up . This is not the casing in masses with a history of blood clot but without COVID-19 . As of now , new avenues with more strong drug and therapies are being looked at to not only deal but also forestall formation of blood clots in multitude with COVID-19 to amend their chances of selection and beat this pandemic successfully.[1 , 2 , 3 ]
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