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Vitamin D is necessary for overall wellness . It plays a purpose in the ontogeny and developing of muscular tissue cells , proper performance of theimmune system , maintaining skeletal health , and more.(1,2 )
The recommended dietary allowance is as follow :
The deficiency of vitamin D increases the risk of exposure of disease , osseous tissue demineralisation , and many negative wellness outcomes.(3)Vitamin D deficiency is super common and it is known that 40 % of US adults are considered to have insufficient vitamin 500 levels and worldwide it impact 1 billion people.(1,2,3)Factors that increase the risk of vitamin d want include:(4 )
As vitamin D deficiency is very common , people supplement it often . Vitamin D supplements are considered secure as a big dose in the dieting is need to keep up with the normal levels.(5)Consuming more than the require dose leads to vitamin D toxicity .
Vitamin D toxicity is usual in people with aesculapian circumstance such as granulomatous disorders , congenital disorders , some lymphoma , and dysregulated vitamin five hundred metabolism . It can occur in the case of accidental overdose , abuse of high vitamin D dose , and ethical drug mistake . It is also known as hypervitaminosis D and vitamin D insobriety .
Effects of Vitamin D Toxicity
1. Elevated Blood Calcium Levels
Vitamin viosterol helps in occupy calcium from the food . mellow vitamin D levels may elevate the calcium level in the stock have potentially dangerous symptoms .
Symptoms of vitamin D perniciousness are relate to symptoms ofhypercalcemia(high atomic number 20 degree in the blood ) , which let in the followers :
Hypercalcemia symptoms take place when a person has a draw out intake of vitamin D for a farseeing point of time .
A case account analyzed that females who ingest an average of 130,000 IU vitamin D for 20 month were hospitalized for symptom related to hypercalcemia.(6)The symptoms included sickness , vomiting , heftiness weakness , and kidney injury .
hypercalcaemia can be life - threatening and needs quick medical attention .
2. Gastrointestinal Symptoms
As excess of vitamin viosterol extend to hypercalcemia that admit gastrointestinal symptoms as well which include :
It was find that a female who live nausea and weight loss was down 78 times more vitamin viosterol than the amount mentioned on the label.(7)The symptom occurred due to highly high doses of vitamin D3 that conduct to an increase in calcium levels .
In another case sketch , it was set up that a boy complained of stomach pain and impairment after taking vitamin 500 supplements improperly while his brother experienced elevated line of descent level without any other symptom.(8 )
One more type subject area found that an 18 months one-time child who was given 50,000 IU of vitamin D3 for 3 calendar month experienced vomit diarrhea , breadbasket pain , and other symptoms.(9 )
3. Altered Mental Status
People with vitamin five hundred toxicity may go through altered genial status due to hypercalcemia . This may lead to symptoms such as disarray , depression , psychosis , and comatoseness in extreme cases .
A pillow slip report of 2021 discover a mankind after having misunderstood the medication educational activity occupy 200,000 IU of vitamin D , show modify mental status and other hypercalcaemia symptoms . He was agitated and obscure in his first 10 days , but the condition meliorate as the calcium level dropped.(10 )
4. Kidney Complications
Vitamin five hundred perniciousness can direct to kidney injury and kidney failure . It happens because excess vitamin D lift the calcium floor in the rakehell , increase the water exit through urination , and leads to calcification in the kidney . It can also cause the blood vessels in the kidney to contract which can further run to decrease kidney function.(11 )
There are studies that show hoi polloi developed moderate to stern kidney injury because of vitamin D toxicity.(12)This is why hold optimal vitamin D floor is important .
Vitamin D has numerous persona to play and it also reduces the risk of certain diseases and better mood and low symptom . It also helps in weight direction . But inordinateness of it also has numerous downsides . Therefore the supplement should be consumed with cautiousness .
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