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Fenoprofen is classified as propionic radical of NSAIDs . The drug was actively research for osteoarthritis . Fenoprofen is in effect NSAIDs to deal joint pain but also require close superintendence . Fenoprofen increase bleed by decreasing platelet function . Relative eminent dosage can cause bleeding in subcutaneous tissue paper and mentality resulting in bruises and solidus . Ibuprofen , ketoprofen , naproxen and Oxaprozin are the other NSAIDs let in in subclass of NDAIDS propionic window pane derivatives . Published data suggests therapeutic dosage of Fenoprofen has tried for 1 to 2 years in patient suffering with chronic arthritis . Long term therapy has not depict any stomachal or intestinal side effect like ulcer and hemorrhage .
Alternative name of Fenoprofen
Also know as Alfon in USA and Fenopron in Europe .
How Does Fenoprofen Work?: Mechanism of Action of Fenoprofen
Fenoprofen decreases synthesis of prostaglandin and other chemical substance bring about in inflammatory tissue . Decrease prostaglandin enzyme cause decrease irritation of pain in the neck receptors and sensory nervus fibers resulting in less painful sensation . Fenoprofen reducing secernment of prostaglandin by blocking the conversion of arachidonic battery-acid to prostaglandin . Cyclooxygenase enzyme 1 ( COX 1 ) and 2 ( COX 2 ) initiates transition of arachidonic dot to prostaglandin and Fenoprofen curb the action of cyclooxygenase enzyme .
Osteoarthritis;Rheumatoid arthritis;Ankylosing spondylitis;Juvenile arthritis;Gout;Tension headache;Migraine .
Dosage of Fenoprofen
Fenoprofen is sold as contraceptive pill and condensation . The condensation and pill are available in engrossment of 200 magnesium , 400 milligram and 600 mg . The pills are dictate 3 to 4 clip a day . Daily dosage is adjusted to total dose of 1600 to 3200 mg per day . Higher dosage between 1600 mg and 3200 mg is expect for joint pain in the neck resistor to smaller dosage when pain is make by rheumatoid or degenerative arthritis . Lower dosages are used in patient hurt with liver and kidney diseases . fenoprofen calcium dosage of 1200 to 1800 mg is been commend for long full term treatment of chronic arthritis .
Duration of Action Fenoprofen
The visor level of Fenoprofen in stemma is observe after 2 60 minutes of taking pills or capsule . The optimal issue last 3 to 4 hours . Most of the Fenoprofen over 90 % is eliminate in 24 hours , thus it is necessary the medicine must be taken at even time interval to achieve consistent pain relief .
Side Effects Caused by Fenoprofen
Allergic reaction could be mild to severe . Severe chemical reaction is rare but rarely can make anaphylactic reaction . Watch for symptoms like sneezing , running nose , trouble in breathing , wheezing , tegument rash , hive , mucosal swelling of sass , tongue and breathing passage . Severe reaction may require emergency intervention call 911 and immediate attention by physician at clinic or ER .
guard want when simultaneously antibiotic , antihypertensive medication , other nonsteroidal anti-inflammatory , diuretic and anticoagulant medication are dictate . Bioavailability of liberal medication is increased and thus low-down dosage may be require to prevent side effects of these medications .
References
Longterm fenoprofen therapy in affected role with arthritic arthritis .
J Rheumatol . 1976;2:43 - 8 . , Roth SH , Englund DW , Harris BK .
Treatment of arthritic arthritis with Nalfon : comparability with acetylsalicylic acid .
Br Med J. 1974 Feb 2;1(5900):176 - 80 .
Huskisson EC , Wojtulewski JA , Berry H , Scott J , Hart FD , Balme HW .
Fenoprofen in the handling of osteoarthrosis .
Curr Med Res Opin . 1974;2(9):551 - 5 . , Wojtulewski JA .
