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Naproxen is class as propionic class of NSAIDs . Naproxen is often second drug of choice of NSAIDs after Ibuprofen . Naproxen is being used since 1976 . Naproxen is widely used to treat joint pain and muscle aches . extend use of naproxen is ward off because of ulceration and bleed disorder . There are several nonsteroidal anti-inflammatory let in under propionic battery-acid derivatives . The five most often used propionic Zen derivative NSAIDs are Ibuprofen , Ketoprofen , Naproxen , Oxaprozin and Fenoprofen
Alternative Name of Naproxen
Naproxen is also known as Aleve , Naprosyn , Anaprox and Flanax .
How Does Naproxen Work?: Mechanism of Action
Naproxen inhibit natural process of Cox enzyme . It blocks conversion of arachidonic acid to prostaglandin . There are two type of cyclooxygenase enzyme known as Cyclooxygenase 1 ( COX 1 ) and cyclooxygenase 2 ( COX 2 ) enzyme . The lack of prostaglandin reduces the severity of inflammation and less temper of painfulness receptor that result in less bother . The want of prostaglandin in stomach and intestine causes ulceration organization . continuing ulcer often stimulate mild to serious bleeding from erode surface of ulceration .
Dosage of Naproxen
Naproxen is usable as straightaway and extended release NSAIDs . The pills are available over the counter in most of the pharmacy . The immediate release pills strength in mg is 200 mg , 250 magnesium , 275 mg , 375 mg and 500 mg . The retard release pill are sold as 700 mg and 1000 mg pill . Naproxen is also sold as unwritten suspension and capsule . Naproxen dose depends on grounds of inflammation of intensity of pain . The dose is 10 to 20 magnesium per kg .
Duration of Action Naproxen
After unwritten administration , plasma level of naproxen are notice within 30 minute of dosing , with vizor plasma grade occurring approximately 5 hours after dose . The observed terminal elimination half - life sentence of naproxen from both immediate release naproxen sodium and NAPRELAN Tablets is approximately 15 hour .
Side Effects Caused by Naproxen
reference work
Naproxen : antirheumatic efficacy and safety in patients with pre - existing GI disease .
Semin Arthritis Rheum . 1988 Feb;17(3 Suppl 2):36 - 9 . , Roth SH1 .
Naproxen effects on learning ability answer to painful press stimulation in patients with knee osteoarthritis : a double - unreasoning , randomise , placebo - controlled , single - dose study . Giménez M1 , Pujol J2 , Ali Z1 , López - Solà M1 , Contreras - Rodríguez O1 , Deus J1 , Ortiz H1 , Soriano - Mas C1 , Llorente - Onaindia J1 , Monfort J1 . , J Rheumatol . 2014 Nov;41(11):2240 - 8 .
Naproxen - induce situate drug volcanic eruption : a case report .
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Efficacy and safety of the COX-2 specific inhibitor valdecoxib in the direction of osteoarthritis of the hip : a randomized , double - unsighted , placebo - controlled comparison with naproxen .
Makarowski W1 , Zhao WW , Bevirt T , Recker stateless person . ,
Osteoarthritis Cartilage . 2002 Apr;10(4):290 - 6 .
