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Dementia is a condition that affects your memory and thinking capabilities . While dementedness is usually thought of to be a part of the born aging cognitive process , there are some conditions like diabetes that can increase the risk of someone developing dementedness . The condition can be debilitating as the symptoms work up . In recent years , there has been a lot of research going on about how to preclude dementedness and slow down cognitive diminution in patient with this experimental condition . Now , a new cogitation has find that atype 2 diabetesmedication known as glitazones can lend about a step-down of 22 percentage in the risk of developing dementedness . Here ’s everything you demand to cognize about dementia anddiabetesdrugs .

What is Dementia?

Dementia is a term used to refer to an overall decline in cognitive acquirement and memory . The disorderliness affects memory , thinking power , and even social abilities in a severe way that disrupts your daylight - to - day lifetime . While it is not one specific disease , but legion diseases can cause dementia . Dementia can be a debilitating condition as it progresses . Alzheimer ’s diseaseis the most commonly known cause of dementedness in older masses . Depending on the cause , signs , and symptom of dementia can sometimes be reversible.(1,2,3,4 )

How is Dementia Tied to Diabetes Drugs?

A newfangled study has now line up that a class of type 2 diabetes drug known as glitazones can reduce the risk of developing dementia by 22 percent . However , since the study was not correlational , it did not find whether film the medications was the primary reason for this observed risk reduction . It is interesting to note that research worker have identified that dementia and type 2 diabetes share several of the same physiological patterns .

The research was conduct by the University of Arizona in the US , and it was a farseeing - term bailiwick that was publish in October 2022 in the BMJ Open Diabetes Research and Care.(5)The study link the employment of this character 2 diabetes drugs , get laid as glitazones , to a 22 pct reduce risk of develop dementia . Glitazones , also known as thiazolidinediones ( TZDs ) , are an one-time family line of drug that Dr. usually no longer dictate for eccentric 2 diabetes.(6,7 )

Comparison of Glitazones With Metformin

Since researchers consider that character 2 diabetes and dementedness share several of the same physiologic properties , many field of study have been carried out to determine whether diabetes drug can aid in the treatment or at least delay the onset of dementia.(8)However , the problem is that the finding so far have remained inconsistent , due to which more inquiry is being carried out .

In line with this , the research team from the University of Arizona carried out a comparison of dementedness endangerment in sr. people who had type 2 diabetes and were treated with TZD or sulfonylurea , which is a very sure-enough class of drugs used to deal diabetes , as compared to those older adults who were being treated with metformin , which is the most widely prescribed diabetes drug used nowadays.(9 )

During this study , the researchers count at the online wellness record of over 555,000 people who were name with type 2 diabetes . The electronic data was access from the national Veteran Affairs ( VA ) Health System , and it ranged from January 2000 to December 2019 . Most of the patients in the database were manlike , whitened , and over half of them were considered to be obese . All of them had case 2 diabetes . The research squad carried out a comparison of the dementia endangerment among the participant maturate 60 years or elder who were being treat with either sulfonylurea or glitazone with those participants who were only pass on metformin during the period January 2001 to December 2017 . The overall health of these individuals was then looked at for closely eight days .

The subject area found that someone who were take glitazone had an 11 pct lesser endangerment of developing Alzheimer ’s disease and a 57 pct decrease hazard of develop vascular dementedness as compare to the participant who were only given metformin . The findings of the field of study also let on that after just one yr of discourse , taking TZD by itself led to a 22 percentage reduce risk of dementedness from any cause as compare to being treated with only the metformin drug . It is important to note that when most patients are diagnosed with mild cognitive impairment , which is ordinarily the precursor to Alzheimer ’s disease , there is a 30 percent peril that they will go on to spring up full dementedness . If such a patient also has type 2 diabetes , they may gain by like a shot switch to using TZD as their treatment , as it can bring about a 22 percent decline in this jeopardy .

Younger People to Experience More Benefits From Diabetes Drugs

The researchers also discovered that the peril for dementedness due to any rationality was 11 percent lower when using a TZD medicine and metformin together . This advise that another alternative to reduce the risk of dementedness is to add on sulfonylurea with Glucophage . At the same prison term , further analysis of the data unfolded a surprising firearm of information that people below the eld of 75 years really get more benefit from using a TZD drug than older patient role .

This finding highlights the importance of starting early dementia bar . The study also designate another surprising fact that these drugs can be more protective and have well benefits for affected role who are obese or overweight .

Why Does This Happen?

One possibility behind why diabetes drugs can lower the risk of dementedness in people with type 2 diabetes is that because of vascular disease , the body ’s blood - genius barrier becomes more holey , which allows more viruses or infection to cross over into the wit , thus leading to the Einstein changes often observed in people with Alzheimer ’s disease . So by , reducing these vascular changes in the brain , it might decrease the risk of exposure factor for dementia or conditions like Alzheimer ’s that have dementedness .

One of the reasons why many patients with eccentric 2 diabetes do not like to use TZDs is because these drugs can lead to exercising weight addition , even though it is minimal and mostly water system of weights . However , TZDs offer many crucial benefits to patients , especially when you check the resultant of the A1C test , which looks at your three - month medium blood sugar levels.(10,11)This class of drugs does not causehypoglycemia , and the reduction in the A1C levels is also quite a draw .

The researchers concluded that even though TZDs may not provide any cardiovascular benefit like Glucophage offers , the important reduction in the endangerment of dementia is essential enough for doctors to start order this class of drugs again , especially in high - peril individual .

Conclusion

One thing that has to be kept in creative thinker , though , is that this study was just data-based , which means that it did not bear witness that the drug make the reduce risk but found that the TZDs drug were link with the simplification . This is why there is a need to conduct placebo - controlled and double - blind clinical trial to confirm whether this drug can actually help decrease the risk of dementia in people with and without type 2 diabetes . you may always need your medico for more information on whether changing your medicinal drug may help if you are at a in high spirits risk of infection of developing dementia or if you have a family history of the condition .

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