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Is Thalassemia The Same As Sickle Cell Anemia?
thalassaemia and sickle cellular telephone anemia , both are genetic disease ofhemoglobinstructure inherit from parents to the children or one generation to other . Thalassemia is not same as sickle cellular telephone anemia disease . They both are different , in sickle cellphone genus Anemia , the shape of the red blood cell or the red blood corpuscles are sickle shaped , which are unable to carry sufficient amount of atomic number 8 to the other body cellphone , whereas in eccentric of Thalassemia there is lack of hemoglobin pigment in the RBCs , so they are unable to carry enough oxygen to the other cell of the body.1Medicineswhich are able to increase the fatal Hb both in Thalassemia and sickle cell anaemia have prove to be quite effective in treating the people suffering from this disease ; however , the drug research for a safer and more effective one is still on . The stem cell organ transplant has also been used for treating both the disorder , but it also has some limitation . Many experiments have been do on animals for long term chastening of these diseases , but it is still not confirmed for humans.2 , 3
History Of Thalassemia
Thalassemia , also fuck as Mediterranean Anemia , was first get word by a Detroit Physician in 1925 . This doc was observing and studying few Italian shaver who were have from life-threatening anemia . These kid had very low level of Hb , protruded belly and former puerility deaths . After studying for few years it was found that the case of Thalassemia is wrong social organisation of the hemoglobin . There are such reactions in the body which destroys red profligate cells resulting in Anemia . To compensate the loss of RBCs , the body protrude producing the erythrocyte at a much fast charge per unit resulting in other complications such as abnormality in the clappers , pearl nub and spleen enlargement.4
Causes Of Thalassemia
Our hemoglobin consists of two proteins , the alpha globin and the Beta globin . Whenever a defective gene is unable control the proper yield of any one of these protein , the effect is Thalassemia . This way the Thalassemia disease is classified into :
Treatment of Thalassemia
Just after one or two decades when Thalassemia was key out , the doctors used to treat this deadly disease by transfusing fresh blood cells in the kid , each month . This method removed most of the puerility problems and symptom and still now it is used as a handling for Thalassemia . However there is another problem of blood blood transfusion which hap in the Thalassemia patients and that is too much deposition of iron in the body . As we all know that blood hold a large amount of iron , which the body is unable to eliminate naturally , so it starts compile in the torso . This branding iron cause too much damage in the adolescent organic structure lead to eventual death of the patients . Later the research was made and it was found that a drug named Desferoxamine is able-bodied to remove spare iron from the body.6This drug helped the patients from developing iron - get heart diseases and the Thalassemia patients were able-bodied to experience much longer .
Currently two other drugs which are consume orally have been discovered and they are quite effective in removing excessive iron from the body . These drugs have been proved to be life saver for the patient who used to be iron overloaded after line transfusion because of Thalassemia . Now the expertise imaging examination are also done which helps in find out amount of iron which is present in the body and to regale them and bump off atomic number 26 from the dead body so that the iron induced substance problems can be prevented.7
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