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Ketoprofen (NSAIDs)
Ketoprofen is a NSAIDs included in propionic grade of non - steroidal ant - seditious drugs . There are 5 nonsteroidal anti-inflammatory included in propionic loony toons derivatives and often used to treat nuisance and excitement . The five nonsteroidal anti-inflammatory drug include in propionic acid derivatives are Ibuprofen , Ketoprofen , Naproxen , Oxaprozin and Fenoprofen .
Ketoprofen like most NSAIDs causes stomachic or duodenal ulceration . Ketoprofen is thus combined with Prilosec , sucralfate and cimetidine to forbid ulcer formation and bleeding . Ketoprofen is been used since 1972 .
Alternative Name of Ketoprofen
Ketoprofen is sell as generic medications . The alternative name for generic medications are Oruvail and Orudis . The local app like ointment and gel are sold as Ketoflam , Fstum and Ketospray . The ointment and gel comprise concentration of 2 - 5 % of ketoprofen and spraying turn back 10 % of combat-ready medications .
Mechanism of Action: How Does Ketoprofen Work?
Ketoprofen therapy provides better pain relief than ibuprofen in patient suffering with joint pain and arthritis . Ketoprofen blocks the action of Cox ( COX 1 and COX 2 ) enzyme and foreclose conversion of Arachnoidic dose to Prostaglandin . The ignition become less hard with absence seizure of prostaglandin that accompany less pain and feverishness . The block of Cox enzyme is reversible . The cyclooxygenase take up normal social function within more or less 72 hours after Ketoprofen is discontinue . fall prostaglandin assiduity in abdomen and bowel causes organization of ulcer and bleeding .
gentle Tissue Pain- Ketoprofen is used to treat acute or continuing rabble-rousing pain due to indulgent tissue paper disease like peel infection , boil and cellulitis .
Inflammation- boil down inflammatory chemical reaction in Joint or cushy tissue paper like skin , subcutaneous tissue , muscle , tendon and ligaments ;
Joint PainandArthritis – Ketoprofen is used as local coating and birth control pill to treat arthritis caused byosteoarthritis , rheumatoid arthritisandankylosing spondylitis . The joint pain in the ass and ivory pain due to disruption and fracture is also effectively treated with ketoprofen .
Musculoskeletal Pain- Musculoskeletal pain following sinew muscle spasm , trauma and tear are process by ketoprofen pills or local software using gel or atomiser .
Neurogenic Nerve Pain- Nerve painful sensation make by sciatic , radicular pain and post - herpetic neuralgy are address with ketoprofen for 10 to 15 days .
Perioperative Analgesics- Ketoprofen is used as premedication in children for perioperative pain . Ketoprofen in injection form has helped to lessen opioid dose during surgery . The effects of analgesic last during mail op period and opioids are avoided in children as a infliction medication following minor surgery .
vexation – Ketoprofen is used as an analgesic to treat latent hostility concern and migraine .
Dental Pain- Dental aches and pain sensation are plow with ketoprofen when patient is unable to brook opioids or refuses to take opioids .
Dosage of Ketoprofen
Ketoprofen is prescribed as a pills , ointment , spray and gel . The local applications like 2.5 % ointment and colloidal gel are sell over the counter in most pharmacy . Some ketoprofen ointment or gel are combined with lidocaine and ketamine to achieve better pain rest period .
Ketoprofen dosage is calculated as 4 to 5 milligram / kgm The birth control pill are sold as 50 and 75 magnesium . The dosage is divided as 1 pill 3 to 4 prison term a day . The farseeing acting pill of strength 200 mg are slow release pills and give once a day .
Duration of Action Ketoprofen
The pinnacle result are observed between 1 and 2 hour after ingestion of pills . The effect last for 2 to 4 hours since ½ life of ketoprofen is 2.5 hours . The total duration of curative effect is 4 to 6 hours .
Side Effects Caused by Ketoprofen
References
Ketoprofen 2.5 % colloidal gel : a clinical overview .
Eur Rev Med Pharmacol Sci . 2011 Aug;15(8):943 - 9 . , Coaccisoli S1 .
Anti - inflammatory and analgesic effect of ketoprofen in palm oil esters nanoemulsion
J Oleo Sci . 2010;59(12):667 - 71 . , Sakeena MH1 , Yam MF , Elrashid SM , Munavvar AS , Azmin MN
Ketoprofen pharmacokinetics , efficacy , and tolerability in paediatric patients .
Paediatr Drugs . 2010 Oct 1;12(5):313 - 29 . Kokki H1 .
Clinical experience with ketoprofen in the management of osteoarthritis and arthritic arthritis .
Md Med J. 1989 Jun;38(6):485 - 8 . , Fine IT .
