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Serotonin is a neurotransmitter or chemical your physical structure produces course . It is require for your brain and nerve cells to function right . However , having too much of serotonin can get various signs and symptom that can graze from being mild to severe . Mild symptoms may include diarrhea and shivering , while austere symptoms can include fever , muscle rigidity , and ictus . Serotonin syndrome can happen when you take sealed medications that induce gamey levels of serotonin to build up in the consistence .
Many types of dietary add-on and illegal drugs can also lead to serotonin syndrome . Severe serotonin syndrome can even be sprightliness - sinister . Here ’s everything you need to love about 5-hydroxytryptamine syndrome .
What is Serotonin Syndrome?
Serotonin syndrome can be a potentially dangerous condition that leads to an accumulation of serotonin in the body as a termination of adverse drug reaction . It happens when too much 5-hydroxytryptamine build up in the body.(1,2,3,4)Normally , the nerve cell in the body give rise serotonin , which is a neurotransmitter , a chemical substance present in the brain .
Serotonin play many important roles in the body and assist order the following in the body:(5,6 )
5-hydroxytryptamine also has a crucial theatrical role to act in ensuring the right functioning of your wit and face cubicle and is also believed to have an effect on your climate .
If you are taking several prescribed medications together , there is a possibility of having too much accumulation of 5-hydroxytryptamine in the body . There are certain types of medications that can induce serotonin syndrome , including drug used for the intervention ofdepression , migraine headaches , andpain managementmedications . Having too much 5-hydroxytryptamine in the body can lead to a kind of symptoms , which can range from mild to severe . These symptoms can involve your muscle , brain , and other parts of the torso as well.(7,8 )
Serotonin syndrome can fall out when you start claim a unexampled medicinal drug that interpose with the trunk ’s born 5-hydroxytryptamine point . It can also occur if you increase the dose of a current medication you are on . The condition is more likely to happen when two or more medication are get together . 5-hydroxytryptamine syndrome can prove to be fateful if you do not get proper discussion .
Symptoms of Serotonin Syndrome
You may see the symptom of serotonin syndrome within hours or even minutes of taking a new drug or increase the dosage of a current medicine . The symptom of serotonin syndrome include:(9,10 )
In more knockout cases of serotonin syndrome may include :
Causes of Serotonin Syndrome
Usually , serotonin syndrome happens when you take two or more medications , nutritionary supplements that increase the serotonin level in the body , or illegal drugs . For example , if you are taking medicine to treat a megrim after already having taken an antidepressant , it can conduct to serotonin syndrome . There are some eccentric of prescription medications , include antibiotics , antiviral for deal AIDS and HIV , and some prescription drug for pain in the neck and sickness are also known to increase the serotonin degree in the body .
Some model of medicament and supplements that can stimulate serotonin syndrome include :
Migraine Medications That Fall Under The Triptan Category
Migraine medications that go to a class of drugs have a go at it as triptans are get laid to be associated with serotonin syndrome . These include:(11 )
antidepressant that are linked with serotonin syndrome include:(12 )
Herbal Supplements
There are some herbal supplement that are known to induce serotonin syndrome . These include:(13 )
Cold And Cough Medications
There are some over - the - counter cold and cough medicines that take dextromethorphan . These medicine are tie in with serotonin syndrome . Some of these include :
Illegal Drugs
There are some illegal drugs that are associated with serotonin syndrome , including:(14 )
Diagnosing Serotonin Syndrome
There is no specific symptomatic trial available for serotonin syndrome . Your doctor will get going by go over your medical history and reviewing your symptoms . It is all important you permit your doctor know if you are taking any medications or use any illicit drug over the last few weeks . Your doctor call for this data to make an accurate diagnosing .
Your doctor is likely to perform some other research laboratory tests as well that will assist them envision out if certain consistence use or organs have been affected . These tests also serve your doctor govern out any other condition .
There are sealed conditions that have interchangeable symptoms to serotonin syndrome , including drug overdose , transmission , and even hormonal problem . A aesculapian condition known as neuroleptic malignant syndrome is also know to have interchangeable symptom to serotonin syndrome . It usually fall out as a result of an contrary reaction to medications used in the intervention of psychotic diseases.(15,16 )
Some of the other science laboratory quiz your doctor may put let in :
Treatments for Serotonin Syndrome
In cases of very balmy serotonin syndrome , your doctor is potential to only recommend that you immediately stop taking the medication that is cause the problem . In cases of severe symptoms , you will need to be hospitalise , where your Dr. will keep a close middle on your condition .
Some of the treatments for severe serotonin syndrome include:(17,18 )
Are There Any Complications of Serotonin Syndrome?
In many cases , severe muscle spasms can make a breakdown of muscle tissue , which can cause severe kidney damage . In such pillow slip , your medico might need to use medicine to temporarily paralyze the muscle to forestall any further damage . A gas helmet and breathing tube might be inserted to help you breathe .
Conclusion
With well-timed treatment , the outlook for serotonin syndrome remains very good . There are unremarkably no further issues once the serotonin level get back to normal . If left untreated , though , serotonin syndrome can shew to be fatal .
It is not always possible to prevent serotonin syndrome . It is authoritative that you let your doc know about all the medicine you are taking to help them check which medicines might be cause your symptom . Your Dr. will continue to supervise you tight if you are hospitalized for the condition . The US Food and Drug Administration requires drug manufacturing business to put monition label on products to warn patient about the possible jeopardy of serotonin syndrome .
References :
