What Causes Duodenal Ulcer?

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What Causes Duodenal Ulcer?

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The upper or proximal GI ( GI ) system includes esophagus , tum , duodenum and jejunum . Middle GI system is formed by small-scale bowel , while distal GI system includes big Costa Rican colon , sigmoid Aspinwall and anus . The stomach continues as a duodenum . The passage of nutrient within the stomach is transmitted to duodenum through a small scuttle known as pylorus . Pylorus is formed by thick layer of smooth muscular tissue . free burning and prolonged contraction of pylorus shut the passage food from stomach to duodenum after meal . The nutrient is grinded and mixed within the breadbasket for continuance of 1 to 3 hours . The digestive process let in gastric juice and eminent assiduousness of battery-acid . The gastric juice hold hydrochloric window pane and maintains humiliated pH. The acidic succus in few somebody redress mucosal epithelial tissue of tum and duodenum . The discredited mucosal level some time forms non healing rear of tube or cracks in mucous membrane known as ulcer . The persistent and repeated disgorgement of venter food mix with eminent acid stomachal succus make esophageal ulcer . The acidic stomachal succus can spark off the organisation of ulcer within the mucosa of esophagus , belly and duodenum .

The ulcer is known as peptic ulcer when gastric acidulent juice cause ulcers within mucosa of stomach , esophagus and duodenum . The duodenal ulcer is observed as individual or multiple ulceration localized in duodenum only .

What Causes Duodenal Ulcer?

Duodenal Ulcer Caused Due to H. Pylori Infection

Bacterial infection such as gastroenteritis is often induce by H.Pylori bacterium . contagion of stomach and duodenum causes excitement of mucous membrane of tummy and duodenum . During the phase of healing of inflammation several mucosal epithelial tissue does not heal into normal endothelial cadre . Thus , follow Helicobacter pylori ( H. pylorus ) contagion the scarred and weak inflamed mucosal epithelium ends up with several ulceration . The ulcers are observe in venter , duodenum or both . The disjunct ulcer focalize in venter is know as stomachic ulcer and ulcer when mention in duodenum is have it off as duodenal ulcer . The Helicobacter pylori ( H. pylori ) bacterial contagion often causes multiple duodenal ulcer .

Duodenal Ulcer Caused Due to Zollinger-Ellison Syndrome

Zollinger - Ellison syndrome(ZE ) is a rare disease . The Zollinger - Ellison syndrome ( ZE ) is do by a single multiple neoplasm that secrete hormone gastrin . The tumour grows within pancreas or duodenum . The endocrine secreted by tumor is known as gastrin . Hormone gastrin stimulates abdomen mucosal cell ensue in increased loony toons synthesis . The gastrin actuate square increase of acid within stomachal juice . The gastric juice in increased volume and lower pH triggers formation of several ulcers in duodenum and tum .

Alcohol Consumption Causes Duodenal Ulcer

societal drink or periodic drinking ofalcoholdoes not cause duodenal ulceration . Heavy regular drinking may have duodenal ulcer . The published scientific articles suggest among the alcohol red wine is less harmful to mucosal epithelial cells.1Alcohol causes microbiological changes in mucosal jail cell take in it vulnerable to bacterial infections followed by mild to serious cell damage follow by ulcer formation.2Persistent mien of alcohol in duodenum weakens the cell allowance and expose mucosal electric cell to harmful effect of acids float in gastric juice .

Chronic Smoking Causes Duodenal Ulcer-

smoke causes decreased oxygenation of mucosal cells and gene mutation . The mucosal cells thus become rickety , and resistant impairment resulting from chronicsmokinginterferes with recuperation of scathe cellphone . Duodenal ulcer is often view in patient who are chain smoker .

Duodenal Ulcer Caused Due to Stress and Anxiety –

The rationality why accent or anxiety do gastric or duodenal ulcer is yet unknown3 . But published scientific articles has suggested that gastric and duodenal ulcers are observed more often in patient who suffer with anxiety or stress.4

Prolonged Consumption of NSAIDs Can Cause Duodenal Ulcer-

Anti - inflammatory medicine such as Motrin , Aspirin and Naproxen are also get laid asnon - steroidal anti - inflammatory drugs or NSAIDs . NSAIDs bottle up the action of Cox enzyme resulting in crushed concentration of intracellular prostaglandin . The good ulcer healing was observed when Research paper publish suggests Proton pump inhibitor increase cellular concentration of COX1 and Cox2 enzyme resulting in rapid ulceration healing.5NSAIDs are widely prescribed in elderly to treatarthritisand pain . nonsteroidal anti-inflammatory stamp down activities of enzyme COX 1 and COX 2 and results in decreased secretion of prostaglandin . Lack of prostaglandin alters the mucosal cell social function and resistance , which is necessary to protect mucosal prison cell from harmful effects of acid and H. Pylori infection.6

remark : The most important steps in diagnosis of abdomen ulcer is to consult a gastroenterologist . The clinical examination , interpretation of finding of examination and analysis of test result has to be evaluated by expert in the subject of gastroenterology system . Our passport is , if you put up with any of similar symptoms then , consult gastroenterologist as before long as possible .