acquire epilepticaphasiais a uncommon childhood disorder , which occurs due to developmental regression . It is an age - related neurologic disorder which is also get laid as aphasia with a convulsive disorder , or infantile acquired aphasia . acquire epileptic aphasia is a reform-minded condition that mainly happen in children of about 6 years of age and is characterized by gradual going of expressive and sensory language ability . Most child affected by Acquired epileptic aphasia also experience epileptic raptus at Nox due to paroxysmal electroencephalographic changes . This syndrome was first discovered by Dr. William M. Landau and Dr. Frank R. Kleffner in 1957 among 6 youngster and therefore the condition is named after the discoverer asLandau - Kleffner Syndromeor LKS .
What is Acquired Epileptic Aphasia?
Acquired epileptic aphasia occurs in the pediatric population and it is aneurological disorderthat principally affects the temporal - parietal regions of the brain . This syndrome is broadly characterized by the rapid or gradual loss of the perceptive language power and unresponsiveness to sound . This is follow by the abnormal electrical wave in the nous as note on electroencephalogram and onset of epileptic seizure . Due to the progress of this syndrome , the child terminate respond to non - verbal sound affiliate with behavioural change .
Symptoms of Acquired Epileptic Aphasia
Acquired epileptic aphasia predominantly occurs in a child between 3 to 7 days of age . However , the onset of the disease can typically happen between 18 months to 13 years of eld . The plebeian clinical signs to key out Acquired epileptic aphasia are mention as follows :
Epidemiology of Acquired Epileptic Aphasia
The prevalence charge per unit of Acquired epileptic aphasia is not much as only 1 or 2 cases are report each year in some specialized centre of attention . male are more prone to develop Acquired epileptic aphasia than female with a ratio of 2:1 . The peak age for the development of acquired epileptic aphasia is 6 class , but the oncoming can be seen from 18 months of age to 15 years . The overriding meter period is 2 geezerhood to 8 years .
Worldwide , 200 or more cases of acquired epileptic aphasia are advert in the medical lit . In between 1957 and 1990 , about 81 cases were reported , with the rate of diagnosis as 100 slip in every 10 long time .
Causes of Acquired Epileptic Aphasia
The literal cause of the occurrence of acquired epileptic aphasia is still obscure and not well - defined . The probable case of Acquired epileptic aphasia may include demyelinating disease , depressed - gradebrain tumour , neurocysticercosis , primal nervous systemvasculitis , unopen - head injury , unilateral brain wound , any sort of infection or inflammatory illnesses , encephalopathic ailments , andautoimmune diseases . Epileptic discharges or seizure are thought to be due to inherent ruffle in cerebral integration or may be because of incapability in processing complex auditory or speech signals . An electroencephalographic irregularity in aphasia is quite common and can come about due to a head wound and astrocytoma in the remaining temporal lobe .
Genetic disposition can also do acquired epileptic aphasia . A mutation in genes like GRIN2A cistron ( 16p13.2 ) and other associated genes , such as BSN , NID2 , RELN , and EPHB2 can also cause take on epileptic aphasia syndrome in infants . Studies have revealed that in some patients acquired epileptic aphasia syndrome occur because of immunosuppression .
Risk Factors for Acquired Epileptic Aphasia
There are no particular peril factor for get epileptic aphasia . If a child manifests any of the above - mentioned symptom , then it is advised to chatter a health care supplier for early detecting and direction of the effort . The potential risk factor are as follows :
Treatment of Acquired Epileptic Aphasia
discussion for acquired epileptic aphasia more often than not comprises ofmedications , behavioural treatment , speech communication therapy , and surgical procedure , all of which should be pop out at an early stage .
Prognosis of Acquired Epileptic Aphasia
The prognosis of Acquired epileptic aphasia usually depart in children , but it is quite good in vitrine of seizure . In the lawsuit of returning to the pre - disease commonwealth , the medical prognosis is irregular . EEG abnormalities and seizures mostly relapse and remit by 15 twelvemonth of age . The forecast for Acquired epileptic aphasia better when talking to therapy starts early . By the starting of the adolescence years or puberty , ictus unremarkably vanish . Neuropsychological disturbances also improve gradually . Even , scant - term remissions are also quite uncommon in acquired epileptic aphasia , but can cause difficulties in different curative sense modality . The prospect for language problem is miserable as language trouble usually continues until maturity and it may take day or old age to recover . Only 10 % to 20 % of patients recover completely . Others develop further complications .
Diagnosis of Acquired Epileptic Aphasia
The coarse procedure for diagnosis involved in the detecting of the acquired epileptic aphasia syndrome includes the following :
Differential Diagnosis for Acquired Epileptic Aphasia
This includes any epileptic seizures include sleep potentiation of epileptic action at law , such as continuous waves or spike during rest , Gastaut , Panayiotopoulos , and other character of rolandic epilepsy and benign infanthood occipital epilepsy . It is important to diagnose autism or a hearing defect which may acquaint as the last sign of acquired epileptic aphasia syndrome .
regrettably , a pediatric population with acquired epileptic aphasia is often misdiagnosed as autism , peripheral audile problem , emotional , behavioural , or cognitive upset , etc cognisance should be created about the signs and symptoms of gain epileptic aphasia . If symptom such as heedlessness to vocalize , fond epileptic seizures stick with by staring , and language simple regression acquire , a physician should be refer immediately . However , right medicines and therapy can help oneself in gradual direction of the symptoms of Acquired epileptic aphasia .
