What is Collagen: Types of Collagen, Genetic Diseases of Collagen

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What is Collagen?

It is usually asked , what is collagen ? Collagen is found in our finger cymbals , muscles , rakehell vessels , digestive system , tendon , and peel . Collagen is what afford our hide its strength and elasticity and also replaces numb skin cells . It is also the ‘ glue ’ that hold our join and sinew together . With age , the production of collagen in the soundbox set forth to decline . Due to this slow down , the body start expose signs of get on such as sagging cutis , wrinkles , as well asjoint pains .

aside from long time , life-style choices we make also has a big role to bet in depleting the organic structure ’s collagen levels . Consuming a diet plenteous in cabbage , smokinganddrinking alcohol , along with too much Dominicus exposure can contribute to lower level of collagen in the body . Collagen - touch on disease arise from a combination of not consuming collagen - robust foods , digestive problems , nutritional insufficiency , and familial defects . Due to the varied location of the collagen types in the body , they are generally associated with a innkeeper of diseases . Collagen - linked disease often lead to problem in the biogenesis of the collagen corpuscle in the body , issues with their fabrication , and also in the post - translational modification routine that creates the last soma of collagen .

Collagen upgrade healing and also provides the best chopine for boosting the growth of novel tissues . Collagen dressings are used to mend several injuries , necrotic lesion , burns and even for skin graft and pelt contribution .

Membranes that are based on collagen are also used in various implant therapy and also in periodontal therapy for promoting the growth of cell of a specific eccentric . Collagen addendum are also used to treat osteoarthritis and in skin revival .

Types of Collagen

There are 28 types of collagen that have been identify in our body to date . However , type 1 collagen make water up almost 90 % of all collagen in the soundbox and is the most common type of collagen in the human body .

Here are the five most common types of collagen in the soundbox .

Genetic Diseases of Collagen

Diseases of collagen normally arise from nutritional deficiencies in the body or from genetic defect . Nutritional deficiencies affect the biosynthesis , assembly , secernment , post - translational modification , or other processes involve in the normal output of collagen . This is a vernacular causa of disease of collagen . Osteoporosis , one of the disease of collagen is not a genetic disease and is because of long time . It is connect by dispirited level of collagen in the skin and bones .

Genetic diseases of collagen can cause defect in not only the general production of collagen but also in collagen secernment . researcher have identified one thousand mutations in twelve types of collagen . These mutations can give rise to various disease of collagen like

Which Genes Get Affected By Collagen Disorder?

get us now take a face at the function of cistron to empathise , which gene is touch by which collagen disorder .

Type I Collagen upset : Present in scar tissue paper and rule in skin , tendons , artery bulwark , fibrocartilage , constituent part of tooth and bones , endomysium of myofibrils , eccentric 1 collagen is the most abundantly available collagen in the eubstance . inherited disorder because of mutations in type 1 collagen include Ehlers - Danlos Syndrome , Infantile cortical hyperostosis orCaffey ’s disease , and osteogenesis imperfecta . These hap in the genes COL1A1 and COL1A2 .

Type II Collagen Disorders : Collagenopathy is the transmitted disorder that go on from mutations make in character II collagen . Type II collagen makes up most 50 per centum of all cartilage protein and it is also find in the vitreous humor of the center . The mutation occurs in the gene COL2A1 .

Type III Collagen disorder : Ehlers - Danlos Syndrome is triggered by a sport in the cistron COL3A1 . Type III collagen is the collagen of granulation tissue . It is produced by unseasoned fibroblasts . It is also happen in skin , bowel , artery wall , and also the womb .

Type IV Collagen upset : Alport syndromeandGoodpasture ’s syndromeis because of a mutation in collagen type IV . Type IV collagen is found in the eye lens system and also as part of the filtration system of rules in capillaries . Mutations go on in the genes COL4A1 , COL4A2 , COL4A3 , COL4A4 , COL4A5 , and COL4A6 .

Type V Collagen disorder : Mutation in type V collagen also causes Ehlers - Danlos syndrome . Genes associated with this disorder are COL5A1 , COL5A2 , and COL5A3 . character V collagen is found is most interstitial tissue paper .

Type VI Collagen Disorders : cistron associate with causing mutation in type VI collagen admit COL6A1 , COL6A2 , and COL6A3 . Conditions which bob up from these mutations include Ulrich myopathy and Bethlem myopathy .

Type VII Collagen Disorders : This type of collagen forms anchoring fibrils in the dermal - cuticular junctions . The mutation occur in the COL7A1 gene and gives rise to the conditions of epidermolysis bullosa and dystrophica .

Type VIII Collagen Disorders : This type of collagen is present in endothelial cells . Mutations of this eccentric of collagen cause ulterior polymorphic and corneal dystrophy 2 . COL8A1 and COL8A2 are the gene associated with the mutations .

Type IX Collagen disorderliness : Mutations occur in the cistron COL9A1 , COL9A2 , and COL9A3 . This type of collagen is present in type II and XI fibrils and also in cartilage . stipulation that arise from mutation in type IX collagen include EDM2 and EDM3 .

Type X Collagen disorder : Schmid metaphyseal and dysplasia are the condition that arise when mutations occur in character X collagen . COL10A1 is the gene in which the mutation occur . This character of collagen is present in mineralizing cartilage .

General Symptoms of Collagen Disorders

While each case of collagen disease has its own unparalleled symptoms , most of them also share some cosmopolitan symptoms . Genetic diseases of collagen too may show these symptom . Patients suffering from collagen disorders usually have the pursuit :

While many people with collagen - based hereditary diseases present with mild symptom , other individuals may have vital complication .

Treatment of Collagen Disorders

The treatment of diseases of collagen differs according to the type of condition you have . However , immunosuppressant medications and corticosteroid are generally used to treat most of types of collagen disorders . Other symptomatic treatment is also used . forcible therapy or aristocratical exercise is also used to treat muscle and joint related symptoms . These exercises will help you retain your mobility and also work towards reducing your body pain .

The long - term outlook of disease of collagen varies from item-by-item to someone . It also depends on the sort of collagen disorder . However , one affair that stay on constant across all the disorder is that such autoimmune diseases are chronic condition and have to be managed throughout your life . They have no therapeutic and medico commonly create a treatment plan that helps to manage the symptoms . Learning how to manage the disorder and its symptoms are important in ameliorate the quality of life .

What is Collagen?#

Types of Collagen#

Genetic Diseases of Collagen#

Which Genes Get Affected By Collagen Disorder?#

General Symptoms of Collagen Disorders#

Treatment of Collagen Disorders#