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What is HER2?
HER2 or human epidermal emergence divisor receptor 2 is responsible for producing HER2 protein that are present on the airfoil ofbreast cancercells . On being activated these protein signal the knocker cancer cells to divide and multiply .
Normally , HER2 proteins play a part in the growth of breast cells , but when their gene is mutate , there is a product of too many HER2 proteins . This causes the uncontrolled growth and division of breast cells . This is seen occurring in about 1 in every 5 compositor’s case of breast cancer and is look up to as HER2 - positive chest cancer(1 ) .
Why Should You Get HER2 Testing Done?
HER2 overconfident breast cancer is aggressive than the HER2 negative unity . They are also likely to recur .
Specially design drugs are useable for treat HER2 positive breast cancer and are also found effective .
If you are abide from breast cancer , you demand to know whether it is HER2 cocksure or not .
FISH and IHC Tests
To determine whether titty cancer is HER2 positive or not , examination is send word that is done on the tissue sample .
The two types of test are ISH or in - situ crossing and IHC or immunohistochemistry .
In Situ Hybridization (ISH or FISH) Tests
An In situ hybridization looks at the genetics of the sample distribution and the results are separate as overconfident , minus , or ambiguous .
If the result is equivocal further examination have it off as Fluorescence in situ hybridisation ( Pisces the Fishes ) , which is a type of ISH , is done .
Sometimes IHC test is done first . If it proves to be inconclusive ISH mental testing is do . It has been find that the ISH test can confirm whether the Crab is HER2 positive or negative .
If the ISH tryout is done first and it is inconclusive , the IHC test is done or the ISH psychometric test is repeated .
In some case , both IHC and ISH tests are needed to confirm the HER2 status .
Immunohistochemistry (IHC) Test
Immunohistochemistry ( IHC ) run watch the quantity of HER2 protein receptor in tit cancer cells .
In an IHC test , the tit tissue is analyzed under a microscope . exceptional stains are used to see how many receptors are present in boob cancer cells . The indication are as follows(2 ):
No further examination is involve if the result are 0 or 1 + . A test depict 2 + is changeable and require further testing .
How is HER2 Testing Done?
To diagnose the HER2 status , some breast tissue paper is off for biopsy . Mild pain is live forthwith after the biopsy . In most display case , Dr. give anesthesia to minimize nuisance .
The tissue is post to a pathology laboratory for reassessment .
Make indisputable whichever lab your sample goes to is reputable and its HER2 examination kit are approved by the Food and Drug Administration ( FDA ) .
Is HER2 Testing Safe And Accurate?
Both IHC and ISH testing techniques are secure . Mostly the testing is done from the original biopsy and would not involve further procedures and can be completed in the doctor ’s role or radiology rooms .
Scar tissue is developed around the biopsy site .
you may confirm from your medico about the accuracy of the test . you’re able to also expect for a second belief from another pathologist .
HER2 target handling are very efficient in plow HER2 positive tit cancers , which are more fast-growing than the other type . Also , the outlook of HER2 has improved over the twelvemonth . It can be because of the new and effective treatment that specifically targets HER2 receptors .
If diagnose with titty cancer make certain that the HER2 test is also performed . Also , if you were HER2 negative and the breast malignant neoplastic disease has recurred , ask the doctor for the need to conduct a HER2 test . titty cancers change status when they repay . HER2 - negative titty cancer may turn HER2 electropositive .
In HER2 confirming cases , treatments are very in effect . Always address to your doctor about the disease and the test being performed and also the treatment option .
