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Indomethacin is being prescribed as NSAIDS for treatment of inflammation and joint pain . Side effects like stomachic ulcer and mucosal bleeding is more often seen following indomethacine treatment compared to most alternative second generation nonsteroidal anti-inflammatory drug . Indomethacine is less oftentimes used because less side outcome are observed with alternative nonsteroidal anti-inflammatory . In most cases anti - ulcer medication like rhinitidine are order at bed time if patient is given indomethacine discussion . The first batch of Indomethacin was manufacture in 1963 . The drug was sell in 1965 .
How Does Indomethacin Work? : Mechanism of Action
Indomethacin is nonselective Cox ( COX ) enzyme inhibitor and blocks COX 1 and 2 enzyme . Like all NSAIDs , indomethacin blocks conversion of Arachnoidic acid to prostaglandin and Thromboxane and Levuloglandin . Arachidonic acid and prostaglandins are found in almost all anatomical sites of human body . Prostaglandin protects stomachic and intestinal mucosal tissue layer and deficiency of prostaglandin causes organisation stomachic and enteral ulcer as well haemorrhage . Increase engrossment of prostaglandin reset organic structure temperature at high layer that results in febrility . Prostaglandin secretion is increase when consistency piano tissue and castanets are wound or infect . Prostaglandin initiates physiologic defence known as inflammation to protect the surrounding normal tissue . NSAIDs like Indomethacin restricts the spread of excitation into normal surrounding tissue , readjust the temperature nub to normal temperature and decreases pain in the neck by drop-off secernment of prostaglandin .
Dosage of Indomethacin
Indomethacin dose is trammel to 50 to 200 magnesium per day . In most caseful symptoms are exempt with 50 to 100 mg dosage . Rarely dosage of 200 mg is used . The medication is prescribed for 10 to 15 daylight .
Duration of Action of Indomethacin
The tip assiduousness of Indomethacin is observed in 2 to 3 minute . Most of the drug is absorb in 4 hour and over 90 % medication is useable , thus therapeutic dosage required is low . In most case 50 mg of Indomethacin give optimal pain relief and apace reduces inflammation .
Side Effects Caused by Indomethacin
References
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