Before the introduction of pharmacological enzyme substitution treatment , the intervention of Anderson - Fabry disease was only symptomatic .
It included analgetic treatment , dialysis , kidney transplant and treatment of the cardiac and cerebrovascular complications .
Symptomatic Treatment
For chronic infliction , it is very utilitarian to use carbamazepine , gabapentin , phenytoin and pregabalin . In eccentric of painful crisis , the use of non - steroidal anti - incitive drugs ( NSAIDs ) or opioids have shown their efficacy .
It is important to avoid intense physical exercising , aroused tenseness and changes in temperature .
For the control of albuminuria ( the comportment of proteins in the piddle ) , inhibitor of the converting enzyme of Angiotensin and Angiotensin Receptor Antagonists are used . A diet low in atomic number 11 and protein is recommended .
In cases of insufficiency , Lanoxin or genus Beta - blockers may be added . If the patient role demo ischemic heart disease , beta - kibosh drug , calcium antagonists or nitrate are indicated . In rhythm disorders , antiarrhythmics , anticoagulants or even pacemakers are used . If dyslipidemia ( it is a quantitative or qualitative disorder of lipids and lipoproteins in the blood ) appears , it can also be dictate statins .
In patients with cerebrovascular disease it will be associated antiplatelet or anticoagulants drug . For gastrointestinal involvement , it can be used pancreatic enzyme , prokinetic , sense organ inhibitor of histamine type 2 ( anti - H2 ) or metoclopramide , but it is also recommended a diet low in fat , with frequent and humbled - volume intake .
In pulmonary impedimenta , it is necessary to bestow a bronchodilator . This is a medication that permit the bronchi to lucubrate so that the gentle wind can flow freely .
What is The Best Medicine for Anderson’s Disease?
Pharmacological Enzyme Replacement Therapy (ERT):
Contraindications of ERT:
Conclusion
It is defined that the ERT has proven its efficaciousness due to the improvement or not worsen of the nephritic , cardiac and neurological functions , but also the gastrointestinal symptom , hearing , peripheral neuropathy , pain , sweating and quality of life history . In the compositor’s case of children , if there is a standardisation of growing and development .
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