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Nickel is a common type of subject matter responsible for for evoke an allergic reply in the form of cutis changes usually pronounce as allergiccontact dermatitis . The chemical mechanism for it is when the body of the patient number in contact with the nickel for the first sentence , which detects nickel as a foreign meat with antigenic properties . After this deduction , the body forms an immune reply against the nickel antigen . This response is a primary immune response because of innate resistance and tries to pass it .
Since the reaction is nonspecific , it is a very mild form of an allergic reaction but at the same metre , the consistency examine to grow the most specific antibody against the nickel antigen and judge to keep it in store of immune organisation with the help of the per cells . It is known as the phenomenon of sensitization .
Once the consistency becomes sensitized to a finicky antigen like nickel , it then forms a lowly resistant reception if the body is give away to the same antigen again . When theimmune systemcomes in contact with nickel again , this time the reaction is much more stern and prolong in time because of preformed antibodies and their computer memory in the resistant system .
What Is The Best Treatment For Nickel Allergy?
The intervention rely on the effort to cut the sensitization of the body against the nickel . Nickel products and ornamentation should not be worn by the people who are at risk of developing sensitising or have already develop it because bar remains the best form of handling in allergic striking dermatitis cause by atomic number 28 .
The best medical treatment uncommitted and in force for the nickel allergy is topical corticoid . These are very powerful in suppressing the local resistant response against the nickel allergy and provide respite to the symptoms like pruritis , oedema , erythema , cyst formation , etc . It down - regulates the process of inflammation by decreasing the cellular response to a foreign antigen .
Topical and local methods for temporary relief let in sop with cool water . Saline water , Burow ’s root , and aluminium acetate can be used for the same but are better than the water in relieving local symptoms[1 ] . Various soothe agent like petroleum jellies are used as emollient which decreases the pruritis and other symptoms of the entropy by reducing the itch to scratch . Topical antihistamine drugs are used sometimes in mild cases but oral antihistaminics are the usually used drugs in temperate Ni allergy[2 ] .
unwritten glucocorticoids are not used unremarkably because these are very effective drugs and are preferred only for wicked cases . A course for a few weeks is require to get the affectional responses by systemic corticosteroids and their dosage is gradually point down . farseeing term use of systemic corticosteroids can be unsafe and increase the morbidness in patients so it should be used judiciously under the fair to middling attention of a recognized health pro preferably a doctor .
Surgical treatment is unremarkably not required but sometimes the bulla become large and fluid - filled which if automatically bristle would leave a big raw surface expanse behind and superadded transmission would spread easily . To foreclose it , healing drain of the bleb fluid with the assistance of a small - bore needle is name and the covering of the bulla is not removed .
Conclusion
nickel note allergic reaction is not a one-time answer and also is not seen on first exposure to it . Prior sensitization is need as a alien antigen for the immune organization to develop antibodies against the nickel and attack it when divulge again . The response could be mild or grievous look upon the amount of vulnerability , the power of the resistant system and other factors also .
Topical glucocorticoid remain the keystone of intervention and hydrocortisone balm is the drug of choice for nickel note allergy . resistant modulators like tacrolimus etc . can also be used in fractious cases . Despite all the handling available , refraining from the nickel - coated substances and ornaments is the better phase of prevention and handling for its allergy .
References
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