Leiomyosarcoma is a malignancy of fluid muscle cell line . Muscles can be nonvoluntary ( no mastery of nervous system ) and voluntary ( under the ascendance of the nervous system ) and smooth muscles are nonvoluntary muscles . bland muscles are found all over the physical structure , thus leiomyosarcoma can hap in all the parting of the eubstance where these set of muscles are find . These let in heart , liver , ancestry vessels , pancreas , GI tract , skin , uterus , GU tract and retroperitoneum . GI tract leiomyosarcoma are now separate as gastrointestinal stromal tumors ( GIST ) . Uterine leiomyosarcoma is the most vulgar among others .
Leiomyosarcoma is also a soft tissue paper sarcoma . indulgent tissues let in muscles , fats , face , tendon , descent and descent vessels . The exact cause of leiomyosarcoma is yet strange and there is speculation around its inherited aptness . Leiomyosarcoma touch both male person and female in an equal ratio ; however , it is more common in adults than in fry / adolescents and come about in 5th or 6th decade of life .
What Is The Prognosis For Leiomyosarcoma?
Leiomyosarcoma is a very rarified tumour and it is prevalent only in 1 % of American population , so the studies on it to meliorate treatment and forecast are circumscribed . Prognosis of the tumor depends on the theatrical production of the tumor along with other factors such as wellness of the patient , prison term of diagnosis , and discussion . The scaffolding on leiomyosarcoma is break by American Joint Committee on Cancer ( AJCC ) , which is as follows :
level 1A : Low grade / size of it less than 5 cm / trivial or deep / no metastasis .
Stage 1B : scummy grade / size less or more than 5 cm / superficial / no metastasis .
stagecoach 2A : Low score / size less or more than 5 cm / deep / no metastasis .
stagecoach 2B : High grade / size less than 5 atomic number 96 / superficial or mysterious / no metastasis .
Stage 2C : High tier / size of it less or more than 5 centimetre / superficial / no metastasis .
phase 3 : high-pitched grade / size less or more than 5 atomic number 96 / recondite / no metastasis .
leg 4 : Any class / any size / any placement / metastasis is present .
Low mark tumors that are localize and detected early have really good prognosis for leiomyosarcoma . High grade tumor have a propensity to distribute quickly and metastasize , thus they have wretched forecast . The survival windowpane for leiomyosarcoma is 5 year . If the tumour is localized then the five twelvemonth survival rate is 63 % . If the tumor spreads to adjacent lymph nodes , then the survival rate is 36 % . If the neoplasm has metastasized , then the survival rate boil down to 14 % . Since , leiomyosarcoma is an aggressive tumor ; it is best when detected early and care for with surgical excision and apropos follow up . This provides good prognosis for leiomyosarcoma patient with greater probability of survival .
Symptoms of Leiomyosarcoma
The symptoms of leiomyosarcoma depend on the location , size and extent of the tumor . In the early stagecoach , leiomyosarcoma may be non - diagnostic . Pain may or may not be present in the touched area ; however , it is not plebeian . The most common symptom is the presence of a growth or a mass in the area . The worldwide symptoms associated with cancer includefatigue , unease , pyrexia , nauseaandvomitingalong withweight red . Other symptoms are specific to the location of the neoplasm such as in uterine neoplasm , the symptoms of unnatural uterine bleeding , unnatural vaginal discharge along with modification in gut and bladder substance abuse are perceive . In gastrointestinal tract tumor , the symptoms will include gastrointestinal bleeding that will ensue in black , tarry and foul smelling stools , abdominal uncomfortableness and haematemesis .
Diagnosis and Treatment of Leiomyosarcoma
A leiomyosarcoma is diagnosed based on the history of the affected role , sign and symptom , clinical evaluation and psychometric test . psychometric test include blood tests , biopsies , FNAC and imagery ( ten - rays , echography , CT scanandMRIs ) . The main aspect of diagnosis is the differentiation of benignant neoplasm from malignant one .
Leiomyosarcoma is make out by oncologists and radiation oncologists . The treatment of leiomyosarcoma highly depends on the staging , grading of the tumor as well as its metastasis along with the age , health and aesculapian circumstance of the patient . Based upon the above factors , the treatment includes surgical extirpation of the tumour in adjunct to irradiation therapy and the chemotherapy .
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