What is Weir-Mitchell Disease?
Weir - Mitchell Disease which is also known by the name of erythromelalgia is an extremely rare pathological condition primarily affecting the lower extremities . The touched individual go through acute burning at the stake and infliction in the lower extremities and in some instance the upper extremity as well . The unnatural member also become intensely erythematous and warm . This is more or less continuous in nature .
Weir - Mitchell Disease normally affects both extremities at one time but in some cases unilateral symptoms have also been demonstrate by the affected somebody . The disease onward motion is super varying in Weir - Mitchell Disease and the severity of the symptom differs on a case to example basis . It has also been seen the onslaught of the condition is also quite variable . In some cases the attack of symptom is pretty gradual and insidious where the affected individual may have symptom which are so balmy that they might not even comment it for long time , while in some case the oncoming of symptom are highly acute and the symptoms of Weir - Mitchell Disease may become severe in a matter of mean solar day to weeks .
There is no known grounds for Weir - Mitchell Disease , although some study suggest that this condition may be make by abnormalcy in the blood watercraft in which there is unnatural bottleneck and dilation of certain line vessels causing abnormalities in the ancestry flow through these vessel .
These abnormality normally occur in line of descent vessels which cater to the blood line supplying to the lower appendage although sometimes the blood line vessels supply to the upper extremity may also get affected as a result of Weir - Mitchell Disease . Weir - Mitchell Disease may come as a exclusive entity or may occur as a solvent of sure implicit in aesculapian conditions . In some cases , a ancestral link has been take down in the exploitation of Weir - Mitchell Disease .
What are the Causes of Weir-Mitchell Disease?
The stem causal agency of Weir - Mitchell Disease is not yet know , but studies suggest that it is caused due to abnormalities in the constriction and dilatation of certain blood vessel , particularly those append blood to the lower extremities and sometimes the upper member which pretend the stemma flow to these region causing the classic symptom of Weir - Mitchell Disease .
Additionally , studies also intimate that one of the cause for the development of Weir - Mitchell Disease is unnatural narrowing of the sphincters of the blood vessels and opening night of the arteriovenous shunt . The role of these sphincters is to control blood flow from the small capillary tube and arteries to the blood vessels .
When the line of descent course through these arteries , they carry with them O and other nutrients along with them . The arteriovenous shunts are bloodline vessel which connect the arteria and veins and function to regulate the temperature of the body . This unnatural narrowing of the sphincters of the blood vessels and opening of the arteriovenous shunt causes increased blood flow rate but decrease oxygen and nutrients in the affected skin surface area causing a sensation of burning , botheration , and erythema of the pelt which are characteristic feature of Weir - Mitchell Disease .
What are the Symptoms of Weir-Mitchell Disease?
The Hellenic presenting feature of Weir - Mitchell Disease is pain , burning , erythema , and warmth in the low extremity , especially the fundament . There can also be swell associated with it . In some showcase , these features may also be see in the upper extremity as well .
These symptoms are experience bilaterally , although in some cases unilateral symptoms are also discover . Unilateral symptoms are mostly observed in cases where certain other aesculapian precondition are responsible for the ontogenesis of Weir - Mitchell Disease .
In some cases the onset of the symptoms are gradual and extremely mild such that the affected individual may not even notice the symptoms for many age whereas in some sheath the symptom onset is extremely acute progressing rapidly in a matter of days to workweek to a serious degree .
In majority of the shell , the symptoms of Weir - Mitchell Disease tend to get high-risk with prison term and the symptoms may start spreading from the low extremity upwards to involve the case as well and from the upper extremities downwards . These symptom tend to get worse with exposure to sun and are relieved when the individual goes to a cooler domain . This is perhaps the symptom which is solely present in cause of Weir - Mitchell Disease .
How is Weir-Mitchell Disease Diagnosed?
The diagnosing of Weir - Mitchell Disease is basically made from the symptom that the moved case-by-case experiences along with a thorough clinical evaluation and tryout . If the affected role has a family history of Weir - Mitchell Disease then it also help in pinpointing towards a diagnosis of this experimental condition .
specialised examination may be done to rein out other circumstance causing similar symptom . The most clinching grounds of this condition is the worsening of the symptom with exposure to sunlight and relief of symptoms when in cooler country . This most confirm a diagnosis of Weir - Mitchell Disease .
How is Weir-Mitchell Disease Treated?
As stated above , easing of symptom can be obtain with enough chilling and thus if an affect soul with Weir - Mitchell Disease is subjected to gradual cooling then he or she may have fill-in of symptom . This is usually done by putting the foot in icing cold water . This provide clamant easement from symptoms of Weir - Mitchell Disease .
Although this material body of handling may take over the symptom but it may lead to certain unsuitable complications like skin injury , blister , infections andskin ulcerswhich may sometimes be nonhealing .
tissue paper necrosis may also occur if the feet re - immersed in ice rink dusty piss repetitively for a long period of meter . Many people with this disorder may also receive symptom relief by placing them in coolheaded surroundings like an air conditioned room .
Elevating the involved extremity is yet another path of free the symptom of Weir - Mitchell Disease . These step may be quite helpful in palliate the symptoms of Weir - Mitchell Disease but on the hindsight such measures may significantly dent the everyday functioning of the affected person due to Weir - Mitchell Disease .
There are also certain medications that can help to alleviate the symptoms to certain level of Weir - Mitchell Disease . Topical medicine have also usher good welfare in relieve the symptoms of Weir - Mitchell Disease .
The most favorite topical agent for relief of symptoms of this condition is lidocaine gel which cloak the botheration impulses and also lighten the symptoms of burn . Some of the unwritten medications that can be used to treat Weir - Mitchell Disease are Ca antagonists , antidepressant , antihistamines , and the like .
It should be noted here that an individual may not find that the medication he or she has been prescribed is effective powerful from twenty-four hour period one . In some cases some medicinal drug may work while other may not . Thus , MD may try a combination of a few medicine until they describe the medication that bests suits the patient role and helps them in relieve the symptom of Weir - Mitchell Disease .
Some patient with Weir - Mitchell Disease may also benefit from a painful sensation management programme in which doctor make use of controlled substances in ordination to relieve infliction so as to help the patients hold out their activity of daily animation which becomes significantly bear on as result of Weir - Mitchell Disease .
